Unusual ligand-dependent chemoselective Suzuki–Miyaura cross-coupling reactions of 3-bromo-4-trifloyl-thiophenes

Abstract An unusual ligand-dependent chemoselective Suzuki–Miyaura cross-coupling reaction for 3-bromo-4-trifloyl-thiophenes was discovered. Pd(PPh 3 ) 4 showed selectivity for triflate over bromide, whereas the selectivity was reversed for Pd( t Bu 3 P) 2 .