Research progress of RNF180 value to the diagnosis of gastric cancer

RNF180 is a novel membrane-bound E3 ubiquitin ligase that participates in cell development, proliferation and apoptosis.It is a tumor suppressor gene that inhibits cell proliferation and induces apoptosis and may inhibit gastric cancer cell lymph node metastasis.The study found that RNF180 gene methylation and gastric cancer is closely related to the occurrence and development.Therefore, RNF180 gene methylation is expected as a tumor marker of gastric cancer for early diagnosis and prognosis of gastric cancer.In this paper, RNF180 on the diagnosis of gastric cancer research progress made a review. Key words: RNF180; Methylation; Gastric cancer; Prognosis; Lymph node metastases