Involvement of 5-HT1 and 5-HT2 receptor activity inmethamphetamine i.v. self-administration in rats depressed byolfactory bulbectomy
2004
The influence of 5-HT1 and 5-HT2 receptor antagonists on
methamphetamine intake was analysed in both, naive rats and
those depressed by olfactory bulbectomy. Our results indicate
that the involvement of 5-HT2 rather than 5-HT1 receptor is
important for methamphetamine reward properties what
corresponds with the outcomes of methamphetamine discriminative
studies. Thus, 5-HT2 receptor antagonists referred to attenuate
the withdrawal signs of drugs of abuse could be of benefit also
in treatment of methamphetamine dependence, mainly in addicts
with depressive disorders.
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