HISTOLOGICAL STUDY OF A PHOSPHOLIPID-BASED PROSTHETIC COATING

Coatings for endo-osseous implants have been developed based on phospholipids. Such coatings promote the formation of a very thin superficial rim which is highly enriched with calcium phosphates.Two phospholipid-based preparations have been compared with a standard hydroxyapatite coating. Preparation S was based on phosphatidyl-serine; preparation C was based on a mixture of phosphatidyl-serine, phosphatidyl-choline and cholesterol. Titanium cylinders spammed with titanium foam were the metallic substrate for the coatings; they were implanted in the femoral canal of New Zealand White rabbits and retrieved after 4, 8 and 26 weeks. A back scattered electron microscopy analysis followed.Both phospholipid preparations were shown not to have any inhibitory action on bone apposition and growth and did not elicit any adverse fibrous reaction. Pictures of bone in-growth into the cavities of the titanium foam are present. A truly tight apposition between bone and coating was evident only in the comparative group s...