Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma

Carsten Friedrich,André O. von Bueren,Larissa Kolevatova,Christian Bernreuther,Tobias Grob,Diego Sepulveda-Falla,Leander van den Boom,Manfred Westphal,Ronald Simon,Markus Glatzel

Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma

2016

Carsten Friedrich
André O. von Bueren
Larissa Kolevatova
Christian Bernreuther
Tobias Grob
Diego Sepulveda-Falla
Leander van den Boom
Manfred Westphal
Ronald Simon
Markus Glatzel

Purpose The aim of this study was to investigate the epidermal growth factor receptor (EGFR) status in ependymoma specimens, as there is a need for new prognostic and druggable targets in this disease.

Keywords:

Targeted therapy
Pathology
Ependymoma
Epidermal growth factor receptor
Copy-number variation
Druggability
Disease
Brain tumor
Biology
Gene duplication

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