EFFECT OF AMIRIDINE ON CONDITIONED REFLEX IN RATS WITH DAMAGED HIPPOCAMPUS

It is shown that even after partial damage to the hippocampus in male rats by quinolinic acid, which causes selective degeneration of hippocampal neurons, their conditioned reflex to time remains impaired for a period of several months. Treatment with amiridine improves the learning of time-interval estimation by such rats and promotes compensatory/restorative processes in the brain. The brain contains a great diversity of connections, and their stimulation may offer an opportunity for enhancing the operation of compensatory/restorative mechanisms in it.