Prognostic factors associated with survival and recurrence in resectable gastric cancer: Retrospective analysis of 379 patients operated at Cremona Hospital from 2007 to 2016.

e16079Background: Surgical resection remains the only curative treatment option for non-metastatic gastric cancer (GC). A large cohort of GCs from a high-volume Italian center was analyzed to describe clinical outcomes and prognostic factors. Methods: 379 GC patients (pts) undergoing curative resection from 2007 to 2016 were considered. Variables analyzed were: age, sex, tumor location (cardia vs non-cardia), histology (intestinal vs diffuse), tumor invasion (T1-2 vs T3-4), nodal status (N0 vs N+), resection margins (R0 vs R1-2), grade (G1-2 vs 3-4), HER2, HP infection, (neo)adjCT, adj CTRT, NLR and lymphadenectomy (D1 vs D2-3). Results: Male to female ratio was 1.5:1. Median age at diagnosis was 75y (IQR 67-81, range 41-92). Histology was intestinal in 68.5% and 11.5% had cardia as primary. HER2 was amplified in 31.6% (available in 98 pts). HP was positive in 20.9%; 46.9% stage I-II, 36.3% stage III and 16.8% with oligometastatic disease. Grouping data by year of diagnosis (2007-2011 for 195 and 2012-201...