Treatment of Thoracic Endometriosis Syndrome: A Meta-analysis and Review

Abstract Background Thoracic endometriosis syndrome (TES) is a rare disorder characterized by the presence of functional endometrial tissue within the chest cavity. Up to 80% of women with TES present with concomitant pelvic endometriosis. The diagnostic-curative path is defined by both thoracic surgeons and gynecologists, consistent with the manifestation of the disease. The aim of the study was to analyze the different approaches to generate an ideal diagnosis-treatment algorithm that can be shared by both specialties. Methods We searched PubMed and Scopus for studies that were completed by March 2019 and that included at least 8 patients with TES. Information on preoperative exams, surgical technique, postoperative management, and recurrence of disease was collected for meta-analysis. Results Twenty-five studies including a total of 732 patients were eligible. Almost all of the patients underwent radiologic pelvis investigation (96%; confidence interval [CI] 87-100). Videothoracoscopy was the preferred surgical technique (84%; 95% CI 66-96). Intraoperative evaluation revealed the presence of diaphragmatic anomalies in 84% of cases (95% CI 73-93). The overall pooled prevalence of concomitant or staged laparoscopy was 52% (95% CI 18-85). Postoperative hormone therapy was heterogeneous with a pooled prevalence of 61% (95% CI 33-86; I2=95.6%; p Conclusions TES should be managed jointly by thoracic surgeons and gynecologists. Chest-abdomen magnetic resonance imaging seems to offer the most details for TES. Combined or staged videothoracoscopy and laparoscopy can provide adequate information to fine-tune proper surgical treatment and postoperative medical therapy.