Comparative efficacy of two fipronil spot-on formulations against experimental flea infestations(Ctenocephalides felis) in dogs
2010
A new fipronil-based spot-on formulation applied once to dogs was evaluated against experimental
flea infestations in a parallel group design, randomized, unicentre and blinded controlled study. Eight
dogs served as negative controls (group 1), eight dogs were treated with a 10% w/v fipronil-based
spot-on solution (Effipro® Spot-on, Virbac SA) at a dosage of 0.67 mL for a dog weighing from 2 to 10
kg and 1.34 mL for a dog weighing from 10.1 to 20 kg (group 2) and eight dogs served as positive
controls (group 3) receiving the original fipronil spot-on (Frontline® Top spot, Merial) at a similar
dosage. Each dog was infested with 100 unfed adult Ctenocephalides felis on days -6, -1, 7, 14, 21, 28,
35, 42, 49, 56, 63, 70, 77, 84 and 91. At 48 h after treatment or re-infestation, each dog was combed
to remove and count live fleas. Geometric mean flea counts obtained were reduced by 99.7 and
100% in groups 2 and 3, respectively on day 2, compared to the negative control group. Dogs were
protected from re-infestations with an efficacy >95 per cent for 93 days in group 2 and for 79 days in
group 3. Both 10% w/v fipronil-based spot-ons, despite different vehicles, were equally able to
eradicate flea infestation, to prevent new infestations and were well-tolerated.
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