Changes of central retinal artery blood flow and endothelial function in patients with coronary artery disease.

2007 
Purpose: In patients with coronary artery disease (CAD), endothelial function is usually impaired, but the parameters of central retinal artery (CRA) blood flow have not yet been investigated. We designed the study to test the parameters of CRA blood flow and brachial artery flow-mediated dilation (FMD), companied by an aim of establishing whether a link may exist between the parameters of CRA blood flow and endothelial function. Methods: Twenty-five subjects were diagnosed as CAD by coronary angiography, and 30 control subjects had normal coronary artery. CRA blood flow and brachial artery FMD were measured noninvasively using high-resolution ultrasound. Results: In patients with CAD, peak systolic velocity (PSV), end diastolic velocity (EDV), and time velocity integral (TVI) of CRA blood flow were significantly lower (8.75 ± 2.09 vs. 10.15 ± 2.16 cm/s, 2.55 ± 0.73 vs. 3.81 ± 0.90 cm/s, 5.01 ± 1.32 vs. 6.27 ± 1.28 cm/s, respectively, p = 0.019, p < 0.01, p < 0.01), conversely, pulsatility index (PI) and ...
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