Relationship Between Physical Properties of Granules by Agitating Granulation and their Tablet

The purpose of this study is to obtain relationships between the physical properties of granules formed by agitating granulation and their tablet in empirical formulas.First, the size distribution, apparent density, hardness and shapes of granules prepared under various granulation conditions were measured, and then the hardness and surface shapes of their tablet was examined.As a result, accounting the physical properties of granules in the condition for tabletting high hardness, empirical formulas for hardness of granules and mean particle diameter were proposed. The formulas accurately expressed the experimental results. The relationships among tablet hardness, pressure, friability, and surface roughness were also discussed.