Human Population Genetics in Aging Studies for Molecular Biologists.

: Testing hypotheses in human populations, then translating such findings into an experimental paradigm to test for causality can accelerate the rate of therapeutic discovery for many aging-related diseases. Integration of human genomics data has become much more accessible to molecular biologists in recent years due to the explosion of data availability and wealth of bioinformatic resources, tools, and methods that work together to minimize barriers related to its use. There are specific skill sets that can promote integration of human data into the work of molecular biologists, which include the ability to download, organize, store, and analyze human genomics data. In this chapter, key considerations and resources are presented, focusing on approaches that might be unfamiliar to molecular biologists, with regard to human subjects protection guidelines, heterogeneity in human genetics, data security and storage, programming languages, and training for data analysis.