Chapter 13:Prospects and Challenges in Molecular Structure Identification by Atomic Force Microscopy

2015 
This chapter covers the emerging use of atomic force microscopy as a powerful tool in the structure determination process. The normal process of elucidating the structure of an unknown compound using spectroscopic methods is described, including the flow of data. Next, the concept of atomic force microscopy (AFM) with angstrom resolution pioneered in the IBM laboratory is introduced. The use of AFM in the structure elucidation process is discussed using an example in which the structure of a known compound is defined using a combination of AFM and mass and NMR spectroscopy. This combination is then applied again to a novel molecule with an NMR-silent region, and a procedure is proposed by which such molecules may be solved in other cases. Limitations of the methodology are discussed and further progress necessary to broaden the application of the technique is covered.
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