Effect of Extracts from Waternut Herb on MCAO Rats

Objective:To study the effects of extracts from waternut herb on MCAO rats and explore its application value in the treatment of cerebral ischemia disease.Methods:75 healthy male SD rats were randomly divided into five groups:control group,models group,water extraction group,alcohol group and control group.Rats were administrated from the 5th after modeling,collecting blood and brain after continuous administration for 21 days.Detecting PT and brain structure.Results:PT was significantly increased when alcohol group compared with control group and model group;Under light microscope,large area of brain tissue necrosis,inflammatory cell infiltration,glial cells and vascular edema,and most neuronal pyknosis,necrosis were seen in model group;Small area of tissue necrosis,inflammatory cell infiltration,occasional blood vessels and glial cell edema could be seen in alcohol group;Water extraction group and control group compared with control group and model group were with no significant difference.Conclusion:Waternut Herb ethanol extracts significantly inhibit the MCAO rat models of thrombosis and improve the condition of brain damage.