Generation of Yellow Fever virus vaccine in skeletal muscle cells of chicken embryos.

Yuli Rodrigues Maia de Souza,Pedro Paulo de Abreu Manso,Barbara Cep Dias de Oliveira,Marcia Andreia Barge Loucao Terra,Thalita Paschoal,Giulia Caminha,Ieda Pereira Ribeiro,Lidiane Menezes Souza Raphael,Myrna C. Bonaldo,Marcelo Pelajo Machado

Generation of Yellow Fever virus vaccine in skeletal muscle cells of chicken embryos.

2019

Yuli Rodrigues Maia de Souza
Pedro Paulo de Abreu Manso
Barbara Cep Dias de Oliveira
Marcia Andreia Barge Loucao Terra
Thalita Paschoal
Giulia Caminha
Ieda Pereira Ribeiro
Lidiane Menezes Souza Raphael
Myrna C. Bonaldo
Marcelo Pelajo Machado

The Yellow Fever (YF) vaccine is produced by the inoculation of embryonated chicken eggs with YF17DD virus on the ninth day of development. Full embryos are collected on the twelfth day of development for vaccine formulation. Skeletal muscle tissue is the main site where biosynthesis of viral particles occurs.

Keywords:

Virus
Skeletal muscle
Virology
Yellow fever
Biology
Embryo
Cytopathic effect
In vitro
Myocyte
Embryonated
In vivo

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