Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity.

Chemical investigation of the ethanolic extracts of the whole plant of Ophioglossum pedunculosum afforded seven new homoflavonoid glucosides, pedunculosumosides A―G (1—7). Pedunculosumosides A and C exhibit modest activity of blocking HBsAg secretion with IC 50 values of 238.0 and 70.5 μM, respectively.