Compared Aerosol Drug Delivery Efficacy of Two Types Nebulizer in Adult Mechanical Ventilator

Background: Aerosol drug delivery through mechanical ventilation (MV) is widely utilized for treating various respiratory disorders. The aim of the study was to compare our novel polymeric vibrating-mesh nebulizer (µMVN + ) to currently used aerosol devices during MV. Methods: A ventilator (Puritan Bennet 760) was set to adult parameters (600 mL, 16 breaths/min) and connected via an endotracheal tube with a filter to a passive test lung. A unit dose of Ventolin (GSK) or Pulmicort (AstraZeneca) was individually added to µMVN + 3.6 (median mass aerodynamic diameter (MMAD) of 3.6µm), µMVN + 2.8 (MMAD of 2.8µm), Aerogen Solo and a small volume nebulizers (SVN), placed at inlet of heated humidifier. Drug captured was eluted and analyzed with a spectrophotometer at wavelengths 276 nm and 254 nm for Ventolin and Pulmicort correspondingly. Results: Figure 1 presented inhaled dose percentages of different nebulizers when aerosolizing Ventolin and Pulmicort. The inhaled dose % with both µMVN + was significantly greater than Aerogen Solo and the SVN ( p p p Conclusions: The novel in-line polymeric µMVN + s were demonstrated superior performance in drug delivery when compared with existing products. Drug formulation influences nebulizer delivery efficacy.