Effects of domperidone on bio-impedance gastric motility of patients with functional dyspepsia.

Objective To investigate the effects on patients of functional dyspepsia(FD)after treatment with domperidone.Methods 30 patients with functional dyspesia according to Rome Ⅲ were collected.The impedance signal and electrical signal were collected at the same time.Symptoms of 30 patients with FD were scored before and after treatment with domperidone 10 mg tid for 1 week.The gastric motility was tested repeatedly for comparison.Results Domperidone can significantly improve symptom scores of abdominal distention,abdominal pain,early satiety and belching(P0.05).The patients with postprandial distress syndrome(PDS) improved significantly(P0.05).The percentage of the power of dominant frequency of electrogastrogram before and after treatment were(52.07±7.01)% and(58.03±8.05)%,the difference was significant(P0.05).There was no difference in the percentage of the power of the dominant frequency of impedance gastrogram with PDS and EPS patients before treatment(P0.05);after Domperidone treatment,that was(46.50±4.08)% for PDS patients and(41.99±3.10)% for EPS patients,the difference was significant(P0.01);the percentage of the power of the whole frequency range had no change in both PDS and EPS groups(P0.05).Conclusion Domperidone can relieve clinical symptom,improve electrical signal,but not impedance gastric motility.The impedance gastric motility of PDS patients improved significantly after treatment with Domperidone when compared with EPS patients.