Systemic IL-10 Release, After a Single Pre or Per Operative Large Dose of ATG-Fresenius in Human Kidney Transplantation

IL-10 is a key cytokine with pleiotropic effect secreted by B cells, cells of the macrophage lineage and also TH0, TH1, TH2 subset. Initialy described as “cytokines synthesis inhibitor factor”, producted by TH2 cells, IL-10 inhibits IL-2 and INF gamma production by TH1 cells. IL-10 has the ability to suppress NIHC II expression and thereby the antigen presentation capacity of monocytes/macrophages. IL-10 also down regulated IL-12 and the production of free oxygene radicals produced by actived macrophage. IL-10 is a chemotactic attractant for CDIr T cells. These multiple suppressive effects on various effector phase of the immune response of IL-10 corrobore the finding that IL-10 is a “natural” immunosuppressor. Systemic effect on all T cells and monocytes occure concomittantly and if IL-10 is present several hours before and on time of transplantation, this realise a veritable “preincubation”, a “bath” of IL-10, leading perhaps to tolerance induction and anergy.