Synthesis of 1-Methyl-4-alkyl-1,3-diacetylenes. Prototropic Rearrangement in 1-Alkyl-1,3-diacetylenes.
2010
Abstract Treatment of 2-methyl-2-hydroxy-6-alkyl-3,5-diacetylenes with powdered NaOH was used for the synthesis of terminal 1-alkyl-1,3-butadiynes that can be isolated (54–97%) or used in situ. In an attempt to increase the yields of some of the obtained products, different experimental conditions were studied and we found that by using CTAB as a catalyst, a prototropic rearrangement was promoted to afford the 1-methyl-4-alkyl-1,3-diacetylenes in the 62–94% yield range.
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