Pharmacological Role of Dietary Polyphenols in Prostate Cancer Chemoprevention

Prostate cancer (PCa) is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable pre-neoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds of dietary origin are available on the market and certainly polyphenols such as epigallocatechin-3-gallate, curcumin, resveratrol, and the flavonoids quercetin and genistein represent those with supposed efficacy against PCa. As shown by many reports on PCa, the use of natural compounds could act against oxidative stress chronic inflammation. Basic research studies have revealed that polyphenols appear to act not only against oxidative stress but also impede pro-neoplastic cancer cell signaling. Although the current studies are limited, mechanisms of action of polyphenols have been confirmed, showing a promising future strategy in prostate cancer chemoprevention.