Immunochemical Methods for Demonstrating Macromolecules in Sympathetic Neurons

Sensitive and specific immunological techniques have been used to localize two macromolecular components of noradrenergic vesicles (chromogranin A and dopamine ^-hydroxylase) in sympathetic neurons. Evidence is provided that they are transported from their site of synthesis in the cell bodies to their site of storage in the terminals from which they are released, probably by exocytosis.