Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

Laboratory for Virology and Experimental Chemotherapy, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium; Laboratorio de Entomologia Medica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Calle 63D 24-31, Bogota DC, Colombia; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands; UMR_D 190 “Emergence des Pathologies Virales” (Aix-Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health), Marseille, France; Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium; Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands