Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

Krzysztof Kiryluk,Li Y,Francesco Scolari,Simone Sanna-Cherchi,Murim Choi,Verbitsky M,Fasel D,Lata S,Sindhuri Prakash,Shapiro S,Fischman C,Holly J. Snyder,Gerald B. Appel,Izzi C,Viola Bf,Dallera N,Del Vecchio L,Cristina Barlassina,Salvi E,Francesca Bertinetto,Antonio Amoroso,Savoldi S,Rocchietti M,A. Amore,Licia Peruzzi,R. Coppo,M. Salvadori,Pietro Ravani,Riccardo Magistroni,G. M. Ghiggeri,Caridi G,Bodria M,Francesca Lugani,Allegri L,Delsante M,Maiorana M,Magnano A,Frasca G,Boer E,Giuliano Boscutti,Ponticelli C,Renzo Mignani,C. Marcantoni,Di Landro D,Domenico Santoro,Antonello Pani,Rosaria Polci,Sandro Feriozzi,Chicca S,M. Galliani,Gigante M,Gesualdo L,Zamboli P,Battaglia Gg,Garozzo M,Maixnerová D,Tesar,Eitner F,Thomas Rauen,Floege J,Kovacs T,Judit Nagy,Krzysztof Mucha,Pączek L,Zaniew M,Mizerska-Wasiak M,Roszkowska-Blaim M,Pawlaczyk K,Daniel P. Gale,Jonathan Barratt,Thibaudin L,Berthoux F,Canaud G,Anne Boland,Metzger M,Panzer U,Hitoshi Suzuki,Goto S,Ichiei Narita,Caliskan Y,Xie J,Hou P,Chen N,Zhang H,Wyatt Rj,Jan Novak,Julian Ba,Feehally J,Bénédicte Stengel,Daniele Cusi,Richard P. Lifton,Ali G. Gharavi

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

2014

Krzysztof Kiryluk
Li Y
Francesco Scolari
Simone Sanna-Cherchi
Murim Choi
Verbitsky M
Fasel D
Lata S
Sindhuri Prakash
Shapiro S
Fischman C
Holly J. Snyder
Gerald B. Appel
Izzi C
Viola Bf
Dallera N
Del Vecchio L
Cristina Barlassina
Salvi E
Francesca Bertinetto
Antonio Amoroso
Savoldi S
Rocchietti M
A. Amore
Licia Peruzzi
R. Coppo
M. Salvadori
Pietro Ravani
Riccardo Magistroni
G. M. Ghiggeri
Caridi G
Bodria M
Francesca Lugani
Allegri L
Delsante M
Maiorana M
Magnano A
Frasca G
Boer E
Giuliano Boscutti
Ponticelli C
Renzo Mignani
C. Marcantoni
Di Landro D
Domenico Santoro
Antonello Pani
Rosaria Polci
Sandro Feriozzi
Chicca S
M. Galliani
Gigante M
Gesualdo L
Zamboli P
Battaglia Gg
Garozzo M
Maixnerová D
Tesar
Eitner F
Thomas Rauen
Floege J
Kovacs T
Judit Nagy
Krzysztof Mucha
Pączek L
Zaniew M
Mizerska-Wasiak M
Roszkowska-Blaim M
Pawlaczyk K
Daniel P. Gale
Jonathan Barratt
Thibaudin L
Berthoux F
Canaud G
Anne Boland
Metzger M
Panzer U
Hitoshi Suzuki
Goto S
Ichiei Narita
Caliskan Y
Xie J
Hou P
Chen N
Zhang H
Wyatt Rj
Jan Novak
Julian Ba
Feehally J
Bénédicte Stengel
Daniele Cusi
Richard P. Lifton
Ali G. Gharavi

Ali Gharavi and colleagues report a genome-wide association analysis of IgA nephropathy in over 20,000 individuals of European and East Asian ancestry. They identify genome-wide significant signals at three new loci near VAV3, CARD9 and ITGAM-ITGAX and correlations between genetic risk and pathogen diversity.

Keywords:

Immunity
Genetic association
Genetic Pleiotropy
Genetics
Locus (genetics)
Population genetics
Nephropathy
Gene
Genome-wide association study
Immunology
Biology

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