Relationship Between Changes of Lymphocyte and Severity of Acute Lung Injury in Patients with COVID-19/ 新型冠状病毒肺炎患者淋巴细胞变化与急性肺损伤严重程度的关系

Objective To analyze the relationship between lymphocyte (LYM) count and the severity of acute lung injury in patients with 2019 novel coronavirus pneumonia (COVID⁃19) Methods 47 patients with COVID-19 were selected in our hospital from January to February 2020, which were divided into the “general group, severe group and critical group” LYM count and neutrophil percentage (NE%) were counted at admission and during hospitalization, and the lung injury score, APACHE Ⅱ and SOFA score were recorded Results The lung injury, SOFA and APACHE Ⅱ scores of critical and severe groups were significantly higher than normal group (P < 0 05) The all scores of critical group were higher than severe group (P < 0 05) Compared with general group, critical and severe groups had lower minimum LYM counts in admission and hospitalization (P < 0 05), while critical group had lower minimum LYM counts compared with severe group (P < 0 01) The severity of acute lung injury was positively correlated with the range of LYM count (P = 0 037) Conclusion LYM count and the range of LYM are important markers which can predict the severity of acute lung injury and prognosis in COVID-19 patients