Hybrid SPECT/CT attenuation correction improves specificity and normalcy rate: A multicenter trial

Abstract Objective: The aim of this multicenter study was to evaluate the diagnostic performance of a hybrid SPECT/CT attenuation correction system for the detection of angiographic coronary artery disease (CAD). Methods: One hundred and fifty-two patients were included in this study. Eighty-three had angiographic CAD ≷50%, 32 patients (pts) had angiographic insignificant CAD (of whom 24 pts had 0% stenosis), and 37 subjects were normal volunteers with Results: Fig. 1 shows the ROC analysis for NC and AC. Using NL as normal reference, specificity was higher as compared to CAD- as normal. Sensitivity, specificity, predictive accuracy and normalcy were improved using AC (Fig. 2>). However, specificity was relative low due to referral bias. Conclusion: CT-based AC SPECT performs better in detecting CAD than NC SPECT, with improved specificity and normalcy rate and preserved sensitivity and predictive accuracy. Download full-size image Figure 1 .