Effect of Poli I:C in murine model of experimental autoimmune thyroiditis

Toll-like receptors (TLR) detect pathogen-associated molecular patters, expressed by bacterias, virus and fungi. TLR are expressed principally in antigen presenting cells (APC). Upon activation the TLR signalling results in the production of several proinflammatory cytokines subsequently inducing an adaptative immune response. The aim of this study was to evaluate mRNA of the TLR3, TLR9 and cytokines (IFN-beta, TNF and IL-1) in thyroid follicular cells obtained of mice with autoimmune experimental thyroiditis (EAT). For that C57BL/6 mice were immunized with Tg plus