Valorization of Small Alkanes by Biocatalytic Oxyfunctionalization.

The oxidation of alkanes into valuable chemical products is a vital reaction in organic synthesis. This reaction, however, is challenging due to the inertness of C-H bonds. Transition metal catalysts for C-H functionalization are frequently explored. Despite chemical alternatives, nature has also evolved powerful oxidative enzymes (e.g. methane monooxygenases, cytochromeP450 oxygenases, peroxygenases) that are capable of transforming C-H bonds under very mild conditions, with only the use of molecular oxygen or hydrogen peroxide as electron acceptors. Although the progress of alkane oxidation has been reviewed extensively, little attention has been paid to small alkane oxidation. The latter holds great potential for the manufacture of chemicals. In this contribution, we therefore will give a concise overview of the most relevant enzyme classes capable of small alkanes (

Keywords:

• Electron acceptor
• Organic chemistry
• Alkane
• Hydrogen peroxide
• Methane
• molecular oxygen
• Catalysis
• Organic synthesis
• Biocatalysis
• Chemistry

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