Антиген фактора фон Виллебранда в оценке функционального состояния эндотелия у больных системной красной волчанкой

Objective. To determine the importance of von Willebrand factor antigen as marker of endotheliae damage at the patients with systemic lupus erythematosus (SLE). Material and methods. 30 women from authentic SLE by criteria ACR, in the age of 20-45 years, with duration of disease not exceeding 5 years are surveyed. More than half of surveyed women had chronic current and 2 degree of activity of disease. Control group have made 20 practically healthy, comparable on age. A functional condition of endothelium estimated by means of brahial arthery dilatation. Concentration von Willebrand factor antigen in blood was determined with I FA. Results. At the pts with SLE the concentration von Willebrand factor antigen authentically is higher, than in group of the control. The high concentration von Willebrand factor antigen correlates withdu- ration of disease, inflammation activity, pathology of kidneys and functional condition of endothelium. Conclusions. The high concentration von Willebrand factor antigen in blood can serve a marker of a kidney pathology and dysfunction of endothelium at the pts of SLE