Pregnane derivatives in position 17 without substituent alpha, their use as medicaments, preparation process, the intermediates of said method and compositions containing them.

The invention relates to the products of formula (I) wherein either R 1 represents halogen, hydroxy, (C 1 C 8) alkyloxy or (C 1 -C 12) acyloxy, and R2 represents halogen or hydrogen or R 1 YR 2 together form a double bond, Z is selected from (C 1 C SUB, 8) alkylthio optionally substituted, arylthio optionally substituted (C 1 -C 8 alkyloxy, cyano, mercapto, thiocyanate and (CH 2) 0 .CO 2H -1 TE EVENTUALMEN esterified Y represents hydrogen or methyl, rEPRESENTING THE STROKES IN POSITION 1-2 dISCONTINUOUS or 5-6 optionally a second link, and its addition salts, THEIR pREPARATION PROCEDURE, THIS intermediaries PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING.