Impact of body mass index on CT attenuation of adrenal adenoma

Abstract Objective To investigate whether lipid metabolism-related factors regulate unenhanced CT attenuation in adrenal adenoma (AA). Materials and Methods Thirty-six patients with surgically proven AAs were enrolled in this study. The patients’ underlying diseases were the following: primary aldosteronism (n = 24), Cushing’s syndrome (n = 8), subclinical Cushing’s syndrome (n = 3) and non-functioning AA (n = 1). Unenhanced CT attenuation of AAs and liver was measured. Pathologically, clear cell ratio (CCR) constituting each AA was qualitatively assessed. Clinical data including tumor diameter, body mass index (BMI), hemoglobin A1c, triglyceride, total cholesterol, blood cortisol and plasma aldosterone levels were also obtained. Simple and multiple linear regression analyses were performed to evaluate the radiological and clinicopathological factors associated with CT attenuation of AAs for all patients and separately for 25 patients with primary aldosteronism or non-functioning AA. Results For all patients, there was a significant correlation between CT attenuation and each of CCR, BMI and blood cortisol levels (p  Conclusion In addition to pathological factors, lipid-metabolism-related factors including BMI and blood cortisol levels can affect unenhanced CT attenuation of AA.