Pharmacognostic and pharmacological study of liquid extract of Crataegus Submollis Sarg. Flowers

The flowers and fruits of various species of the hawthorn genus ( Crataegus L.) are widely used in domestic and foreign medical practice as cardiotonic agents. A perspective species for collecting of the raw material is Crataegus submollis Sarg. It was determined that 70% ethanol is an optimal extragent for the extraction of flavonoids from Crataegus submollis Sarg. flowers. The content of the total flavonoids in terms of hyperoside in the liquid extract of Crataegus submollis Sarg. flowers is 0,24 ± 0,01%. It was established that liquid extract of Crataegus submollis Sarg. with using of 70% ethanol in case of a single intragastric administration in the dose of 100 μl/kg shows significant antidepressant activity. Crataegus submollis Sarg. flowers are the perspective medicinal plant raw materials.