Anti-human Notch4 antibody

【Task】 Anti-human Notch4 antibody or Notch4 binding fragment thereof may have a neutralizing activity against human Notch4, and provides a pharmaceutical composition containing them as active ingredient. A The present inventors, have high neutralizing activity and binding affinity to human Notch4, acquires the mouse anti-human Notch4 antibody identified a sequence of complementarity determining regions of the mouse anti-human Notch4 antibody (CDR) . Thus, making the humanized antibody comprising the CDR sequences of the mouse anti-human Notch4 antibody variable regions of the heavy and light chains becomes possible.