Relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure

Objective To investigate the relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure. Methods We examined the levels of asymmetric dimethylarginine (ADMA) in the serum and urine of 29 hemodialysis patients using the HPLC method, and assessed the relationship between serum ADMA and blood pressure. Results The level of serum ADMA was higher, but the level of urinary ADMA was lower in the patients with chronic renal failure than those in the controls. The serum ADMA was positively related to blood pressure. Conclusion The accumulation of ADMA may be related to hypertension in patients with chronic renal failure.