Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer

Much of what we know about the signal transduction machinery of the canonical Wnt pathway comes from studying the colon, where low- versus high-activity Wnt signaling states are known to distinguish normal colon epithelium turnover from colorectal cancer. Here, Fancy et al. demonstrate that a pathological Wnt activity state akin to that in colon cancer exists in oligodendrocyte precursor cells in human neonatal white matter injury, which leads to detrimental maturation arrest of these cells. These oligodendrocyte precursors in human newborn brain injury express multiple genes in common with colon cancer, demonstrating a pathological Wnt tone in non-genetic human disease.