Effect of high intensity interval exercise rehabilitation in cystic fibrosis

The effects of pulmonary rehabilitation in cystic fibrosis are well documented, but the effectiveness of interval exercise has not been thoroughly explored. The aim of this study was to investigate whether interval exercise (IE) could be as beneficial as constant-load exercise (CLE) in cystic fibrosis. We studied 24 Caucasian, ambulatory cystic fibrosis patients. Patients underwent a structured, outpatient, hospital-based rehabilitation program (duration: 12 weeks). Patients were randomized either to high-intensity IE (n=12) or moderate intensity CLE (n=12). Both interventions were balanced to provide the same overall training work load. In both groups, the maximum work rate was significantly improved following the completion of the rehabilitation program: in IE Group by 12% (pre: 89±56, post: 108±60 watt; p=0.001) and in CLE Group by 8% (pre: 93±49, post: 109±59 watt; p=0.001). Moreover, the 6MWT was also significantly improved in the IE Group (by 45 m: pre: 538±70, post: 583±83 m; p In conclusion, within the pulmonary rehabilitation setting, IE is equally effective to CLE in improving functional capacity. However, it can be applied to CF patients with lower dyspnoea sensations and higher blood oxygen saturation, thus qualifying as a safer alternative.