Derivatives thieno (3,2-c) pyridin-7-carboxylic acid.
2007
Compounds of formula I: ** (See formula) ** in which: R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6, C1-C6 alkoxy, cyano , NR4R5, trifluoromethyl and NO2, R2 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 substituted alkyl, aryl or C1-C6 heteroaryl-substituted alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cyano, halogen, NR4R5, methyl sulfonyl, sulfonamide, trifluoromethyl, sulfonyl urea, amide, ester, carbamoyl, carbamate and urea, R3 is selected from the group consisting of hydrogen , hydroxy, C1-C6 alkyl, C1-C6 alkyl, C1-C6 alkoxy and NR4R5, R4 and R5 is selected from hydrogen, C1-C6 alkyl, C1-C6 alkyl substituted by hydroxyl or C1-C6 alkoxy, R6 is C1-C6 alkyl substituted by hydroxyl, Q is O or NH, rings a and B are aryl, heteroaryl or substituted heteroaryl, the XY linker selected from the group consisting of -OCH2-, -CH2O-, -NHCO-, -CONH-, -O-, -OCH2CH2-, -CH2OCH2-, -CH2CH2O-, -CF = CH-, -CH = CF -, -NH-, -NHCH2-, -CH2NH-, -SCH2-, -CH2S-, -SOCH2-, -CH2SO-, -SO2CH2-, -CH2SO2-, -S-, -CH = CH- and C1 XY-C6 alkyl or may be a single bond, with the proviso that, in the event that XY is a single bond, ring B is a substituted or unsubstituted heteroaryl selected from the group consisting of: ** (See formula) ** and pharmaceutically acceptable salts thereof.
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