Comparison of two kinds of therapies for children with simple urinary tract infections

OBJECTIVE To study the therapeutic effect of single-dose antibacterial therapy and 10-day therapy on children with simple urinary tract infections and provide reference for the clinical treatment of the children with simple urinary tract infections.METHODS A retrospective analysis of the clinical data of 117children with simple urinary tract infections enrolled from Jun 2010 to Jun 2012 in the hospital was performed.Patients were divided into two groups:single-dose therapy group(52cases)and 10-day therapy group(65 cases)according to the therapy method.The therapeutic outcomes were observed at two time points:4dand 11d.RESULTS There were 38cases with positive results of urinary bacterial culture on the 4th day after treatment in the single-dose therapy group,with a positive rate of 73.08%;there were 47cases with positive results of urinary bacterial culture on the4th day after treatment in the 10dtherapy group,with a positive rate of 72.31%,showing no significant difference between the two groups;on the 11th day after treatment,the positive rates of urinary bacterial culture in the single-dose therapy group and 10-day therapy group were 69.23% and 58.45% respectively,showing significant difference between the two groups(P0.05).The incidence and recurrence rates of adverse drug reaction of children in the single-dose therapy group and 10-day therapy group were 7.69%,15.38% and 15.38%,3.08% respectively.CONCLUSIONThe 10-day therapy has a higher efficiency and lower recurrence rate than those of the single-dose therapy for children with urinary tract infections;so it is suitable for the clinical applications for the children with urinary tract infections or the children who are ineffective to single-dose antibacterial therapy.