Endometrial hyperplasias immunohistochemical aspects

UNLABELLED: Endometrial hyperplasias are now diagnosed according to the histopathological examination. By using immunohistochemistry, the authors search for supplementary elements for the diagnosis and evaluation of the prognosis of this nosologic framework. MATERIAL AND METHODS: We investigated a number of 138 cases of endometrial hyperplasia, using immunohistochemical research. The avidine-biotin-peroxidase method revealed estrogenic and progesterone receptors, together with EGF, proliferative Ki67 and cyclin D1. RESULTS: The reaction was positive in variable percents for estrogenic receptors, especially for complex atypical hyperplasias. A positive immunoreactivity was also found for progesterone receptors and for Ki67 (in atypical hyperplasias); cyclin D1 revealed only a moderate reaction. CONCLUSIONS: Immunohistochemistry can be useful for the prognosis of the lesion, but it is not indispensable for diagnosis, while the histopathologic examination is absolutely necessary for a complete endometrial hyperplasia diagnosis.