Effects of A Novel Disc Formulation on Dry Mouth Symptoms and EnamelRemineralization in Patients With Hyposalivation: An In Vivo Study
2017
Background: The goal of this study was to identify the in vivo effects in patients with hyposalivation of a novel
slowly dissolving adhering test disc upon on enamel remineralization, oral biofilm, salivary production, pH and
buffering, gingival health, and on self-evaluation of oral well-being.
Methods: Five subjects with xerostomia wore custom made retainers carrying 5 demineralized enamel chips for
periods of 1 week each. In 1 study arm, subjects used the test agent plus oral hygiene self-care; in the other they
used oral hygiene self-care only, with a 1 week washout in between arms. The treatment sequence was randomized.
Before and after each study arm Plaque Index (PI), Gingival Index (GI) and Sulcus Bleeding Index (mSBI) were
recorded. Clinical plaque staining was quantified using digital image analysis. Saliva production, pH and buffering
capacity were recorded. Subjects completed a self -evaluation questionnaire for oral comfort. Enamel samples
underwent standardized Knoop microhardness testing to quantify mineralization status. Results: Plaque presence and clinical Plaque Indices decreased significantly with test agent use (p<0.05). Fiveminute
saliva production almost doubled 10 and 40 minutes after oral test disc insertion (significant, p<0.05).
Salivary pH buffering improved in 4/5 subjects with disc use. All demineralized tooth samples re-hardened intraorally
(p>0.05). The discs favorably impacted eating problems and dental sensitivity. Subjects were positive about
disc flavor and mouth feel.
Conclusion: Using established in vivo techniques, the effects of a novel product in xerostomic patients were
evaluated and quantified. The adhering disc facilitated eating, reduced dental sensitivity, improved saliva production
and buffering capacity, reduced plaque, and alleviated xerostomia symptoms.
Clinical Relevance: Xerostomia management is challenging. A novel dry mouth disc was effective in alleviating
dry mouth symptoms.
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