Pouvoir interférogène du vaccin antirabique préparé sur cellule rénale de fœtus bovin: étude de la cinétique de la 2-5a-synthétase chez uhomme après vaccination

Summary Interferon-induced 2′,5′-oligoadenylate (2–5A) synthetase was measured in circulating lymphocytes of mice and men vaccinated with rabies vaccine prepared on foetal bovine kidney cells (FBKC). Two peaks of enzymatic activity were observed, on days 1 and 11–21 post-immunization in man. FBKC vaccine also induced in vitro a 2–5A-synthetase increase when incubated with lymphocytes from the 9 subjects under test, before immunization. However, the in vivo results and the in vitro non-sensitized-lymphocyte interferogenic activity of this vaccine did not seem to be correlated. Thus, it is suggested that interferon may be involved in immune reactions occurring after antirabies vaccination.