Data-based algorithms and models using diabetics real data for blood glucose and hypoglycaemia prediction - A systematic literature review.

Abstract Background and aim Hypoglycaemia prediction play an important role in diabetes management being able to reduce the number of dangerous situations. Thus, it is relevant to present a systematic review on the currently available prediction algorithms and models for hypoglycaemia (or hypoglycemia in US English) prediction. Methods This study aims to systematically review the literature on data-based algorithms and models using diabetics real data for hypoglycaemia prediction. Five electronic databases were screened for studies published from January 2014 to June 2020: ScienceDirect, IEEE Xplore, ACM Digital Library, SCOPUS, and PubMed. Results Sixty-three eligible studies were retrieved that met the inclusion criteria. The review identifies the current trend in this topic: most of the studies perform short-term predictions (82.5%). Also, the review pinpoints the inputs and shows that information fusion is relevant for hypoglycaemia prediction. Regarding data-based models (80.9%) and hybrid models (19.1%) different predictive techniques are used: Artificial neural network (22.2%), ensemble learning (27.0%), supervised learning (20.6%), statistic/probabilistic (7.9%), autoregressive (7.9%), evolutionary (6.4%), deep learning (4.8%) and adaptative filter (3.2%). Artificial Neural networks and hybrid models show better results. Conclusions The data-based models for blood glucose and hypoglycaemia prediction should be able to provide a good balance between the applicability and performance, integrating complementary data from different sources or from different models. This review identifies trends and possible opportunities for research in this topic.