A Facile Synthesis of Chiral N-Protected β-Amino Alcohols.
1991
Abstract Chiral N-protected β-amino alcohols are easily obtained by NaBH 4 reduction of mixed anhydrides of N-protected α-amino acids in an organic/aqueous medium. The alcohols obtained from side chain or main chain reduction of N-protected aspartic acid are converted in good yields into lactones.
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