Synthesis and biological evaluation of C-1 and ring modified A-norpaclitaxels
1999
Abstract 1-deisopropenyl-1-acetoxy-A- nor paclitaxel, 1-deisopropenyl-A- nor paclitaxel, 1-deiso-propenyl-1-acetyl-8,9-oxido-A- nor paclitaxel, and A- nor -C- nor paclitaxel were synthesized. The biological activities of these analogs were determined, and structure-activity relationships for the C-1 position are suggested.
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