UNIT 12.1 Biosafety in Handling Gene Transfer Vectors
2003
This unit is devoted to safety issues that must be considered when generating and working with vectors for gene therapy. A short description of the relevant regulatory bodies and mechanisms is followed by a general discussion of containment and safety procedures. This is followed by vector-specific guidelines for nine commonly used vector systems, including adenovirus, vaccinia, HSV-1, lentivirus, and nonviral vectors. Recent tragic experiences with retroviral integration near oncogene loci demonstrate the surprise effects of successful gene therapy. The unit also outlines the problems encountered when taking a promising vector to clinical trials.
Keywords:
biosafety;
gene transfer;
vectors;
hazards;
risks
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
24
References
0
Citations
NaN
KQI