A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

Abdul H. Khan,Lauren L. Kolb,Melissa Skibba,Markus Hartmann,René Blöcher,Ewgenij Proschak,John D. Imig

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

2018

Abdul H. Khan
Lauren L. Kolb
Melissa Skibba
Markus Hartmann
René Blöcher
Ewgenij Proschak
John D. Imig

Aims/hypothesis The metabolic syndrome is a cluster of risk correlates that can progress to type 2 diabetes. The present study aims to evaluate a novel molecule with a dual action against the metabolic syndrome and type 2 diabetes.

Keywords:

Type 2 diabetes
Diabetic nephropathy
Agonist
Endocrinology
Drug development
Metabolic syndrome
Epoxide hydrolase 2
Peroxisome proliferator-activated receptor
Internal medicine
Diabetes mellitus
Biology
Glucose tolerance test
Insulin resistance
Fatty liver

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