SAT0076 Serum level of syndecan-4 and its correlation with clinical parameters in rheumatoid arthritis patients

Background Heparan sulfate proteoglycan syndecan-4 plays an important role in inflammation. However, the role of syndecan-4 in rheumatoid arthritis (RA) has not yet been elucidated. Objectives To detect serum level of syndecan-4 in RA patients and investigate its correlation with RA clinical parameters. Methods The concentration of serum syndecan-4 was assayed by enzyme-linked immunosorbent assay (ELISA). 43 patients9 serum samples from our RA cohort study between 2014 and 2016, and 20 age- and gender-matched osteoarthritis (OA) patients9 serum samples were collected and analyzed. Compared the serum syndecan-4 levels in RA patients with DAS28≥3.2 and DAS28 Results Baseline serum syndecan-4 levels of RA patients were significantly higher than the matched OA patients (1101.56 pg/mL vs 281.41 pg/mL, p Conclusions Compared with age- and gender- matched OA patients, serum syndecan-4 concentration is significantly higher in RA patients. Serum syndecan-4 level is positively correlated with RF. Syndecan-4 may play an important role in thes pathogenesis of RA. Further investigation is required to study the mechanism of syndecan-4 in RA. References Zhao J, Guo J, Wang L, et al. The role of a proliferation-inducing ligand (APRIL) in the pathogenesis of rheumatoid arthritis. Scand J Rheumatol 2014;43(6):462–9. Patterson AM, Cartwright A, David G, et al. Differential expression of syndecans and glypicans in chronically inflamed synovium. Ann Rheum Dis 2008 May;67(5):592–601. Endo T, Ito K, Morimoto J, et al. Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation. Arthritis Rheumatol 2015 Sep;67(9):2512–22. Acknowledgements We are indebted to all the patients who kindly participated in this study. This study was partly supported by Peking University Clinical Research Institute. Disclosure of Interest None declared