Pyrimidopyrimidine ketone compounds, pharmaceutical compositions and uses

The present invention provides represented by the formula (I) or (II) 7- (substituted amino) -3,4-dihydro-pyrimidine [4,5-d] pyridin - (1 hydrogen) - for the preparation of ketone compounds, medicament for the treatment of tumor. The study confirmed that they had more inhibition of tumor cell proliferation, inhibition can be used to target the epidermal growth factor receptor kinase (EGFR), in particular, effective to inhibit EGFR (T790M) mutants single point mutation is a point mutation or cancer. Therefore useful as anticancer drug EGFR inhibitors have great value.