DNA Variants in NOS3 Are Associated with Improved Small Artery Elasticity and Decreased Systolic Blood Pressure in Asymptomatic Individuals

Fourteen miRNA transcripts were quantified following reverse transcription and realtime polymerase chain reaction; expression levels were normalized to an internal control. After testing for normality, group comparisons were performed using a ttest. ROC curves were generated to evaluate diagnostic utility of miRNA expression. Results: No age or gender association was observed with any miRNA expression. Of 14 miRNA tested, 6 were significantly associated with ISHF, 5 with ID-HF and 4 with both (Table 1). By ROC analysis miRNA expression robustly differentiates HF groups from HC (Table 2).