7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.

George Martin Buckley,Nicola Cooper,Hazel Joan Dyke,Fiona P. Galleway,Lewis Gowers,Joanna C. Gregory,Duncan R. Hannah,Alan Findlay Haughan,Paul G. Hellewell,Hannah Jayne Kendall,Christopher Lowe,Robert James Maxey,John Gary Montana,Robert J. Naylor,C.Louise Picken,Karen Ann Runcie,Verity Margaret Sabin,Bishwa R Tuladhar,Julie B.H. Warneck

7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.

2000

George Martin Buckley
Nicola Cooper
Hazel Joan Dyke
Fiona P. Galleway
Lewis Gowers
Joanna C. Gregory
Duncan R. Hannah
Alan Findlay Haughan
Paul G. Hellewell
Hannah Jayne Kendall
Christopher Lowe
Robert James Maxey
John Gary Montana
Robert J. Naylor
C.Louise Picken
Karen Ann Runcie
Verity Margaret Sabin
Bishwa R Tuladhar
Julie B.H. Warneck

The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).

Keywords:

Enzyme
Chemical synthesis
Phosphoric Diester Hydrolases
Asthma
Phosphodiesterase Type 4
Organic chemistry
Biochemistry
Chemistry
Enzyme inhibitor
Phosphodiesterase

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations